Biopolymers and cell. 2003; 19 (6): 548 - 552

Antitumor activity among derivatives of the 3-chloro-4-(3-hydroxyanilino) -2,5-dihydropyrrole-2,5-dione

S. S. Tarnavsky, G. G. Dubinina, S. M. Golovach, S. M. Yarmoluk

Fourteen derivatives of the 3-chloro-4-(3-hydroxyanilino)-2,5-di-hydropyrrole-2,5-dione with various substituents at 1 and 3 positions of maleimide cycle have been synthesized and tested for antitumor activity in vitro. Ten compounds have been selected after pre-screening and tested on 52 human tumor cell lines. It has been revealed that 1 -(2,3-dichlorophenyl)-3-chloro-4-(3-hydroxyanili-no)-2,5-dihydro-lH-2,5-pyrroledione and l-benzyl-3-(3-hydroxy-anilino)-4-phenylsulfanyl-2,5-dihydro-lH-2,5-pyrroledione suppress growth of some cancer cell lines with G/50 < 0.5 • 10 M and 10 M.