Biopolymers and cell. 2003; 19 (6): 536 - 540

Analysis of C282Y and H63D mutations of the hereditary haemochromatosis gene HFE among the Ukrainian population and patients with brain glial tumor

V. M. Pampukha, V. D. Rozumenko, A. P. Cherchenko, L. A. Livshits

The research deals with the spreading of C282Y and H63D mutations of hereditary chromatosis gene HFE among the inhabitants of various regions of Ukraine as compared to the people with brain tumors. It was found that t he frequency of C282Y mutation is 2.5 % within the whole population of Ukraine whereas it is 2.9 % for the eastern regions, 2 % for the central regions, 2.5 % for the western regions, and 1 % as for the Crimean Tatar population. The frequency of H63D mutation within the whole population is 17 %. As for the people suffering from brain tumors (86 patients investigated) a tendency of decreasing H63D-mutated heterozygotes has been shown.