Biopolymers and cell. 2003; 19 (5): 445 - 450

A role of tyrosine kinase Syk during neuronal differentiation of raurine embryonal carcinoma cells PI9, stimulated by retinoic acid

V. M. Kukharskyy, E. Draberova, Ya. B. Blame, P. Draber

Using a culture of murine embryonal carcinoma cells stimulated by retinoic acid as a model of neuronal differentiation the changes in the tyrosine kinase Syk expression during neuronal differentiation have been shown. Study on the Syk tyrosine kinase distribution in both soluble and insoluble, enriched by elements of cytoskeleton, fractions of cells, has revealed first the endocellular redistribution of tyrosine kinase Syk during neuronal differentiation. A possible interaction of tyrosine kinase Syk with cytoskeleton elements is assumed.