Biopolymers and cell. 2003; 19 (4): 374 - 377

Search for antioxidants among derivatives of S-(quinaldine-4-yl)-L-cysteine

A. A. Brazhko, L. A. Omelyanchik, D. M. Fedoryak, J. F. Belenichev, M. P. Zavgorodny

Toxic, antioxidant and ccrcbroprotectivc activities of several deri¬vatives of S-(quinaldine-4-yl)-L-cysteine have been studied. It has been shown, that all investigated compounds normalize a Level of antioxidant enzymes, reduce the products of free radical oxidation and their activity exceed a known antioxidant dibunole. It has been established, that their activity substantially depends on a nature of the substituent in the position 6 of a quinoline cycle.