Biopolymers and cell. 2003; 19 (2): 190 - 195

A role of immunogenetic markers in development of genetically determined pathology

D. V. Zastavna, O. Z. Gnateiko, C. V. Makukh, O. I. Terpylyak, Z. O. Nadyuk

Pecularities of the major histocompatibility complex (MHC) DQA1-allele distribution in the parents of children with Down's syndrom and/or cystic fibrosis have been studied considering that both immunological status of organism and its susceptibility to a specific disease are determined by the MHC function. The data obrained allow to regard autoimmune thyroiditis as a potential risk factor for the aneuploidic posterity. They also predict that elevated expression of the major histocompatibility class II DQAl0501-allele, responsible for the susceptibility to autoimmune processes, especially for diabetes type I, may cause the cystic fibrosis manifestation of pancreatitis in the patients with major delF508-mutation.