Biopolymers and cell. 2003; 19 (1): 19 - 30

Molecular mechanisms of astrocytic gliomas carcinogenesis

O. M. Garifulin, V. V. Dmitrenko, V. M. Kavsan

Basic genetic alterations which lead to forming the astocytic gliomas of grade II—IV are described in the review. The data concerning the genetic elements, participating in the malignant transformation of astocytic cells, are summarized. Tlie molecular mechanisms of the arising de now and developing of the secondary astrocytic tumors are analyzed. The molecular characteristics of carcinogenesis of different malignancy grades astrocytic gliomas are compared. The general and specific elements that determine the-malignant progression of astrocytic gliomas are described.