Biopolymers and cell. 2002; 18 (6): 540 - 546

Interaction of cyanine dyes with nucleic acids. Spectral-luminescent properties of pyryllum and pyridinium mono/trimethincyanines

V. B. Kovalska, I. V. Valyukh, O. M. Kostenko, S. Yu. Dmitrieva, 0.1. Tolmachov, S. M. Yarmoluk

The spectral-luminescent properties of series of pyrylium and pyridinium mono- and trimethincyanines as possible fluorescent dyes for the nucleic acids (NA) detection and labeling were studied. We propose 3,6-methUendioxy-benzothiazolomonomethinepyridocy-anine MDO40 for using in homogeneous assay, as well as for the construction of otigonuleotides-based «light-up probes».