Biopolymers and cell. 2002; 18 (3): 253-254

Among Escherichia coli Genetic Stock Center strains many are resistant to cytotoxic antimetabolites

CHEREPENKO E. I. , KARPENKO O. I.

Mutants resistant to cytotoxic antimetabolites arise in E. coli with a frequency about 10~4. Because most in this collection strains contacted a mutagen we checked how many strains could tolerate two inhibitors used: glyphosate and 6-aza-uracil. Among 28 strains studied 12 could tolerate these inhibitors.