Biopolymers and cell. 2002; 18 (3): 237 - 242

New 6-azauracil derivatives — amides of as-triazine carbon acids: their synthesis and antimicrobial activity

I. V. Alexeeva, L. I. Palctiikovskaya, S. N. Hwchenko, E. V. Baschta, M. O. Platoiwv, V. G. Kostina, L. S. Usenko, N. A. Lysenko, V. A. Motto

Three series of new 6- azauracil derivatives, differing by structural motives of the spacer linking a heterocycle with carbamide fragments have been synthesized and researched on the basic principles of bioisosterism concept. The antimicrobial activity of these new compounds has been detected in test-cultures of bacteria, micelial and yeast-like fungi. The results obtained indicate that the 6-azauracil-5-propanic and 5-thioacetic acid derivatives can be mo¬dified to enhance significantly their antibacterial potency.