Biopolymers and cell. 2002; 18 (2): 161 - 163
Antiviral properties of de now designed proteins based on the albeferon and the fragment LKDRHDF (3036) from human interferon-a2
R. V. Chertkova, N. A. Stepanenko, D. A. Dolgikh
Two biologically active de novo proteins, ABB1-11 and ABBI-1, were engineered by including the fragment LKDRHDF (3036) from human interferon-a2 (HuJFN-a2) into the N- and C-termini of albeferon de novo protein with pre-designed structure and function. It was shown that both proteins prevented the destruction of the L-41 and VERO cell monolayers generated by cytopathical action of a virus with the efficiency of native HuIFN-a2 and did not possess cytotoxicological properties.