Biopolymers and cell. 2001; 17 (6): 560 - 564

Synthesis of novel 2',3'-dideoxy-6-azacytidine derivatives — potential retroviral reproduction inhibitors

KOSTINA V. G., ALEXEEVA I. V., PALCHIKOVSKAYA L. I.

This paper deals with the synthesis of the novel 2',3'-dihalo-2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy-analogues of 6-azacytidine as potential antiviral substances. The compounds were prepared by means of the appropriate reagents — triphenylphosphonium halogen salts. The first step of the 6-azacytidine conversion results in 2,3-epoxynucleosides as against deoxygenation of uridine and thymidine, when 02, 2'-cyclonucleosides are generated.