Biopolymers and cell. 2001; 17 (5): 441 - 447

The investigation of ceruloplasmin influence on the experimental myosin-induced myocardial damage

L. L. Sidorik, V. I. Bobyk, O. M. Fedorkova, D. V. Ryabenko, O. V. Sergienko, I. V. Tntnina, O. V. Koroleva, Ye. V. Stepanova, Yu. N. Gusarova, G. Kh. Matsuka

The data on influence of different doses of ceruloplasmin on the autoimmune myosine-induced myocardial damage like dilated car-diomyopathy obtained on the mouse model are presented. The level of autoantibodies directed against the human and mouse myosins has been examined. The cardiomyocites morphological injures have been revealed by a hystochemical assay at different stages of the disease progression. We have shown dose-depended cardioprotective and immunomodulating effects of ceruloplasmin.