Biopolymers and cell. 2001; 17 (5): 434 - 440

Correlation of HLA-DR antigens, level of immunogenetic indexes and morphologic changes of the thymus gland at myasthenia

E. M. Klimova

The key risk factors inducing the changes of thymus gland at myasthenia are different and their role is not studied completely. A possible correlation of isoantigen phenotypes HLA-DR with the character of ultrastructural pathology of thymus gland and the changes of immunoreactivity at myasthenia has been studied in this work. 70 % correlation with HLA-DR5 at the hyperplasia of thymus gland has been revealed. In patients with tumoral lesion of mediastinum the reliable increasing of IgE and IL-4 levels has been observed in 87.S % cases. A high level of correlation with isoantigen HLA-DR7 (66 %) has been revealed at thymomas.