Biopolymers and cell. 2001; 17 (5): 428 - 433

Heparin and rat brain heparin-binding proteins take part in the process of hyperalgesia

G. A. Ushakova, 1. N. Kornilovska, Y. Y. Kobeliatsky

It was shown that a hyperalgesia state resulted in the decrease of the mast cell degranulation degree and therefore diminished the amount of free heparin. In-parallel, the augmentation of heparin-binding activity of the rat brain proteins in hemispheres was detected. The morphine or ketamine application 5 min prior to operation preserves the heparin-binding activity of these proteins at the preoperative level