Biopolymers and cell. 2001; 17 (2): 109 - 139

Problem of tumor origin as it is from the molecular genetics point of view

V. A. Kordyum

The problem of oncogenesis from the point of view of molecular genetics is analyzed. The special attention is paid to the genome instability as the main reason of the malignant cells growth. It is pointed out that the genome instability provides the material for the selection. An immune control system destroys everything what it can destroy. But at the same time it creates the «own» tumor for each patient, which is not recognized by the immune control system as a harmful one.