Biopolymers and cell. 2001; 17 (1): 36 - 42

Staphylococcus toxin modulates the regulatory mechanisms of contraction-relaxation of ring smooth muscles of the thick intestine

T. L. Davidovskaya, O. V. Tsimbalyuk, M. S. Miroshnichenko

The influence of_ Staphylococcus toxin (ST) of con¬centration 1,6 • 10 —1,6 -10 Lh on the contractile activity of thin (150—200 pm) smooth muscle stripes from guinea pig caecum caused by acetylcholine or high potassium solution and caffeine has been studied. It has been found that ST changes the permeability of L-type Ca channels dose-dependently and inhibits the caffeine-induced contraction of muscle stripes. ST modulates the realisation of a neurotransmitter signal along the electrical and pharma-comechanical ways of excitation-contraction coupling in smooth muscle cells.