Biopolymers and cell. 1999; 15 (5): 402 - 408

Specific transfer factor to Staphylococcus aureus antigens influences on the activation of caecum smooth muscle contraction

T. L. Davidovskaya, N. S. Miroshnichenko, N. P. Fadeyenko, N. V. Davidovskaya, L. S. Kholodnaya, T. A. Lyubchenko, O. G. Goleva

The influence of a transfer factor of cell-mediated immune response (TF) (IQ^—IO mg/ml) on the guinea-pig taenia coli smooth muscle contraction was investigated under isometric conditions by tensometric method. It was found thai TF stimulated potential-de¬pendent cell membrane Ca + reallocations, changed the cations transport system sensitivity in sarcoplasmic reticulum, inhibited contraction of pharmaco-mechanical coupling type by dose-depend¬ent manner.