Biopolymers and cell. 1999; 15 (5): 390 - 394

Influence of antioxidants on catalytic activity of the respiratory chain of mitochondria electronic transport in rat liver at paracetamol intoxication

I. S. Blazhchuk, V. N. Kovalenko, A. M. Shayakhmetova, A. K. Voronina, I. V. Kuzmenko

Over 2-fold increase in superoxide anion and hydroperoxide level was revealed in tat liver mitochondria at acute paracetamol into¬xication. It is accompanied with about 35 % decrease in both NAD-and succinate-cytochrom-c oxidoreductase activities. Pcroral admi¬nistration of two a-tocoferol acetate derivatives with different length of a isoprenoid chain promotes an increase in antioxidant status of mitochondria and reduction of the activity of the enzyme systems independently on the structure of the side chain of vitamin E analogs.