Biopolymers and cell. 1999; 15 (4): 328 - 336

Interaction of cyanine dyes with nucleic acids. 8. Investigation of cyanine dyes as fluorescent probes for the nucleic acids detection

S. M. Yarmoluk

The nineteen polymethyne cyanine dyes with various heterocycles were investigated as possible fluorescent probes for the homogeneous nucleic acid detection in solution. Absorption and fluorescent properties of these dyes, their complexes with DNA and RNA and in the presence of protein were studied. A possible model of «viscous environments for intensity enhancement of cyanine dyes in their fluorescent complexes with nucleic acids was proposed.