Biopolymers and cell. 1999; 15 (4): 289 - 291

The influence of low doses of radiation on the content of superoxide dismutase RNA in different tissues of mice

V. I. Prima, E. I. Martynenko, Yu. V. Vagin

The content of mRNA coding copper-zinc superoxide dismutase (CuZn-SOD) was studied in cells of different tissues of mice. With the help of DNA-RNA hybridization it was found that long effect of low doses of radiation causes the inhibition of CuZn-SOD trans¬cription In spleen and testicle and stimulates the gene expression of this enzyme in liver and brain of irradiated animals. The question about possible participation of CuZn-SOD in rod lores istance of mammals cells is discussed.