Biopolymers and cell. 1999; 15 (4): 262 - 274

Does nitric oxide regulate the tumor necrosis factor signal transduction?

M. Yu. Obolenskaya, A. A. Samoilenko

This contribution is focused on the potential role of the nitric oxide in the perception and the intracellular transduction of tumor necrosis factor (TNF) signal. The data about concerted activities of TNF and nitric oxide in different physiological and pathophy-siological processes are presented. Particular attention is paid to the structural peculiarities of TNF intercellular messengers that provide the possible interaction of nitric oxide with these messengers. On the basis of conducted analysis and the existing data about nitric oxide interaction with some intercellular messengers of TNF signal transduction it is suggested that nitric oxide plays a definite role in manifestations of multiple TNF functions.