Biopolymers and cell. 1998; 14 (4): 332 - 342

Polymicleothle inhibitors of virus reproduction (alkylated nucleic acids, iintiseiisc RNAs and ribozyme)

A. D. Shved

The review contains previously obtained data on the experimental research of polynucieotide inhibitors of virus reproduction in models of RNA and DNA containing viruses. The antivirus properties of nucleic acids isolated from various sources were revealed, but their alkylated derivatives inhibited virus reproduction more efficiently The endogeneous synthesis of antisense RNA provided essential inhibition of HIV-i replication in human hematopoietic cell, cul lures. The ribozyme capable to cleave specifically HIV-1 tat RNA in vitro wits synthesized and cloned.