Biopolymers and cell. 1998; 14 (3): 223 - 230

Regulation of the type I interferon genes and interferon-inducible genes. 1. Organization of the promoter regulator;' sequences

A. V. Karpov

A review of information concerning the regulatory motifs in the genes coding the 1 type interferons (a- and fl-lFNs) and 1FN-inducibie genes is presented. The structural properties of the domains realizing both positive and negative expression regulation of these genes as well as the functional peculiarity of such sequences in heterologous promoter structures have been described. Taking into account the novel data the significance of regulatory sequences conformation above and in transcriptional complexes for the effec-tivity of the interferon genes expression is emphasized.