Biopolymers and cell. 1998; 14 (3): 210 - 222

Signalling molecules in regenerating liver

M. Yu. Obolenskaya

This contribution is focused on the kinetic and causal correlations between production of intercellular signalling molecules and bio¬chemical events in the regenerating liver after partial hepatectomy. The events of individual cell cycles, particularly their DNA syn¬thesis, are used as the reliable time-markers of regenerating process. The signalling molecules produced in regenerating liver are repre¬sented by cytokines, derivatives of arachidonic acid and inorganic molecules as nitric oxide, riiey regulate the functional activity of each other and form the common system of intrahepatic com¬munication. Particular sett of acting signalling molecules are typical for the different phases of liver regeneration. The liver transit from the relative quiescence to the proliferation and the initial pro-tiferative response of the hepatocytes are predominantly regulated by the signalling molecules produced by the sinusoidal cells. The