Biopolymers and cell. 1997; 13 (4): 335 - 339

Comparative studies of inhibitory action of synthetic, natural and complex preparations on HIV-1 clinical isolates obtained in Ukraine

S. V. Antonenko, O. V. Barbashcva, A. V. Karpov, N. Ya. Spivak

In in vitro experiments using an acute HIV-infection model and clinical H1V isolates the authors have made comparative studies of modified nucleosides (AZT, D4T) protective action, the preparation being of different producers, as well as of polyribonucleic interferon inducers and of molecular complex yeast KNA — tilorone. It was found that, modified nucleosides producled in Ukraine do not significantly differ from foreign ones in their protective effect and their inhibitory action on p24-antigen synthesis, whereas interferon inducers is less effective, moreover yeast RNA — tilorone molecular complex acts better latest ones, and approach to nucleoside preparations according this effectivity. Taking into account the difference in the both type preparations meclwnisms of action it was done conclusion about effectivity of their combined usage in AIDS therapy.