Biopolymers and cell. 1997; 13 (4): 285 - 290

N^-deriva tives of 6-azacytidine: synthesis and biological activity

I. V. Alexeeva, L. I. Palchikovskaya, A. S. Shalamay, S. S. Tarnavsky, L. M. Nosach, V. I.. Zhiovnovataya, N. S. Dyachenko

Different methods of the synthesis of N^-derivatives of 6-azacytidine in conditions of simplified «sililic condensation methods were investigated. T/wir antivirus activity with respect to the serotype 2 adenovirus in the culture of Hep-2 cells was studied. Primary specific activity of the compounds obtained was defined. Correlation between chemical structure of the new 6-azacytidine derivatives and its biological properties is discussed.