Biopolymers and cell. 1997; 13 (2): 108 - 112

A change of conformation properties of cellular phospholipids effected by molecule of pyrazole

R. S. Nasibullin, M. A. Serebrenik

A change of conformation properties of phosphatidylcholine under the formation of its complexes with pyrazole due to hydrogen binding P-O ... N-H (type I complex), and the interconnection of n-pyrazole molecule system with a polar hea of phosphatidylcholine (type II complex) have been studied by means of quantum chemistry methods. The development of type I complex has been shown to lead to conformation changes of phospholipid involving a gauche-conformation as a more preferable for phosphorilcholine part of phospholipid.