Biopolymers and cell. 1996; 12 (6): 25 - 35

The influence of heterogeneity of somatic mammalian cell system on mutagenesis manifestation induced by transforming genes of adenovims

S.I. Lukash, L.L. Lukash

In this paper on the basis of literature and own data analysis mathematical model of manifestation of induced mutagenesis have been proposed talcing into account heterogenicity of cell generation period in the system oncogenic adenovirus — somatic mammalian cell. The influence of some parameters which being used for creation of mathematical model on dynamics of mutagenesis have been carryed out. Results of theoretical computations and experimental measurements have been compared.