Biopolymers and cell. 1996; 12 (3): 47 - 53

The activity of antioxidant enzymes and free-radical processes in neurones cells nucleus under low-dose irradiation

A. F. Protas

The external gamma-irradiation of rats under 0.1—I Gy alters the activity of nuclear superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GP) and glutathione-reductase (GR). The activity of SOD is maximal at the first two days after irradiation. Irradiation not alters the summal CAT and GP activity. The activity of GR decreased just after irradiation, but it is restored in 5 days. This process is correlated with decreasin of the reduced glutathione. The increasing of stabile free-radical productes is observed. It has some dependence on dose of irradiation. The model analysis of purified CAT, GP and GR showed, that unde exposure with free radicals the activities of these enzymes are decreased.