Biopolymers and cell. 1996; 12 (2): 34 - 37

Effect of linolenic acid and its hydroxamic derivative on 5-lipoxygenase

L. B. Bondarenko, S. A. Ohiy, I. A. Butovicfl

In experiments with micellar in vitro system comparative study oflinoleic and linolenic acids and also their hydroxamic derivatives effects on 5-lipoxygenase from potato tubers was carried out. It was shown that less effectivness of linolenic acid as substrate of 5-lipoxygenase (in comparison with linoleic acid) correlated with less inhibitory effect oflinolenate hydroxamic acid (in comparison with linoleate hydroxamic acid) on this enzyme. Effects of investigated compounds depended on pH and substrate concentrations.