Biopolymers and cell. 1996; 12 (2): 29 - 33

Hydroxamic derivatives of saturated fatty acids as inhibitors of 5-lipoxygenase

L. B. Bondarenko, S. A. Ohiy, V. N. Tsernjuk, I. A. Butovich

In experiments in vitro were established inhibitory effects ofhydroxamic derivatives ofstearic, palmitic and caprilic acids on 5-lipoxygenase from potato tubers. Their effects depended on pli and substrate concentra¬tions and were independent — on time of incubation of enzyme with inhibitor. Hydroxamic derivative of stearic acid was the most effective inhibitor among investigated compounds. Sliortening of fatty acid side chain lead to sharp decreasing of inhibitory effect.