Biopolymers and cell. 1996; 12 (1): 5 - 15

Characteristic features of specific fermentative function of thrombin and it's connection with the structure

A. A. Sereyskaya

This review deals with thrombin peculiarities responsible for its highly selective and effective action in blood clotting system. Role of enzyme additional binding-recognition exosites in interaction with fibrinogen is analyzed. As a result ofthrombin-fibrinogen recognition complex formation is supposed some conforma-tional changes to arise that couple exosite with active centre and accelerate the catalytic process.