Biopolymers and cell. 1995; 11 (2): 82 - 87

DETECTION OF STRUCTURAL CHANGES OF NUCLEIC ACIDS UNDER THE ACTION OF 2',5'-OLIGOADENYLATES

Z. Yu. Tkachuk, A. V. Kozlov, L. V. Tkachuk, T. I. Phylozop, I. A. Mikhailopulo

The possibility of certain core 2',5'-oIigoadenylates effect on the structure of nucleic acids was studies in cell culture in vitro. These compounds were shown to induce single-helical regions rise in the structure of nucleic acids using S] nuclease enzyme. These effects are accompanied by their low penetration into the cells.