Biopolymers and cell. 1994. Volume 10. № 3-4. 103 - 104

I. G. Skripal', S. V. Bezugly, V. V. Babitschev

INDIRECT DETERMINATION OF THE 5'->3' AND 3'->5' OF THE DNA-DEPENDENT DNA-POLYMERASE FUNCTION

Summary

    Doxorubicin in the concentration of l mg/ml and streptonigrin in the concentration 1000 mg/ml each agent separately should by useful to determination of replicative (5'->-3') or reparatlve (3'->5') function DNA-polymerase. This enzymes with 5'->-3' fully inhibited by doxorubicine but net sensitive to action of streptonigrin in concentration substances mentioned above. And contraverse, DNA-polymerase with 3'-*-5' function don't sensitive to doxorubicin and it's activity depressed by streptonigrin.