Biopolymers and cell. 1993. Volume 9. № 6. 41 - 49

ORLICHENKO L. S., BEREGOVSKAYA N. N., LITOSHENKO A. Ya.

The Aging Dependent Effects of Proteins and mtDNA Content in Mitochondrial Fractions of Rat Liver

Summary

    The contents of mtDNA and proteins encoded by mtDNA and nDNA were determined in liver mitochondrial fractions of rats of different ages (young — 3—4, adult — 6—8, old — 24—26 mo). Three mitochondrial fractions with different sedimentation constants have been varied by content and ratio of mtDNA and proteins as well. The absolute and relative content of the fractions were changed irregularly in liver mass unit with age. Furthemore, it was observed that the content and ratio of mtDNA and proteins changed in each mitochondrial fraction with age. These changes were more pronounced in the old rats as compared with adult ones. The mechanisms of coordination alterations of mitochondrial genome replication and expression are discussed.