Biopolymers and cell. 1993. Volume 9. № 5. 19 - 25

BEREGOVAJA E. G., GORYSHKO A. G., CHECKMAN I. S., DUNAYEV V. V., SACHENKO L. G.

Influence of Antiarrhythmic and Nootropic Drugs on Model and Biological Membranes

Summary

    Membranotropic action of antiarrythmic and nootropic drugs (anaprilin, etmozine, carnithine, piracetam, phenhisole, ksantiverine, phenoxanone, compounds E and VS) was studied on lyposomes from lecithine, cardiolypine and synaptosomal membranes of rabbit brain by means of spectrofotometry and spectrofluorometry using fluorescent probes of pyrene. The ability of these compounds to form complexes with lipid bilayer, increase of its motility, was shown. The studied physiologically active compounds decrease calcium-binding properties of synaptosomal membranes and of bilayer from cardiolypine.