Biopolymers and cell. 1993. Volume 9. № 4. 105 - 108

GRISHKO V. I., MALARCHUK S. G., LIVSHITS L. A.

Polymorphism of pERT Locus of Dystrophin Gene in Families with High Risk of Muscular Duchenne Dystrophy and within Healthy Women from Ukraine

Summary

    RELP-analysis in polymorphic systems pERT87-8-BamH!, pEK'1'87-8-XtnnI, pERT87-15-Taq! of dystrophin gene performed in 28 families with high risk of muscular Duchenne dystrophy. This systems were diagnostically informatived for 26 families. The distribution of RELP-genotypes of pERT locus was found for 97 healthy women from Ukraine. The necessity of analysis of intragenic and Flanking markers RFLP for effective diagnosis of muscular Duchenne dystrophy is discussed in this report.