Biopolymers and cell. 1993. Volume 9. № 1. 54 - 58

GALAGAN N. P., RASPOPINA V. A., PROKOPENKO V. V., BOGOMAZ V. I.

Use of High-Dispersed Silice for Obtaining of Biologically Active Drug Mixtures

Summary

    The adsorbtion abilities of disperse silica with hydroxygroups on sur¬face on to proteins of native mixtures of biomolecules (non-purified preparates of micro¬biological, animal and plant origin) in the presence of carbohydrates (polysaccharide, glycoproteins, monosaccharides). The difference having place in this process depending on participation of one or ano¬ther carbohydrate are obtained. The possibility of intermolecular interaction between the proteins and polysacchari-des, was observed having been in one and the same preparation and silica's ability to change them. It was shown that in biologically active mixtures of plant origin the monosacchari¬des can sorbe upon the SiO2> in presence of proteins, which is impossible in model experi¬ments. The mechanism process is discussed. The data obtained may be used in purifying the biopolymers by inorganic sorbents.