Biopolymers and cell. 1992. Volume 8. № 5. 16 - 20

YARMOLUK S. M., KOROL L. S., ALEKSEEVA I. V., SHALAMAY A. S.

Oligonucleopeptides. II. Synthesis of Oligonucleotidyl-(P→N)-Peptides Using Oxidation-Reduction Reagent-Triphenylphosphine, 2,2'-Dipyridyldisulfide

Summary

    We studied the formation of P-N bond in the oligonucleopeptides of phosphoramide type with use of oxidation-reduction reagent — triphenylphosphine, 2,2'- dipyridyldisulfide in the presence of various nucleophilic agents. Reaction depended on pKa of iaminogroup of peptides. Highest yields were obtained using peptides with pKa about 9. The method allows to prepare oligonucleopeptides bouth at 31'- and 5'-terminal phosphate groups.