Biopolymers and cell. 1992. Volume 8. № 4. 3 - 19

SIDORIK L. L.

Protein Biosynthesis and Autoimmunity

Summary

    Literature data on the peculiarities of autoantibodies biosynthesis against some components of translation apparatus are presented in this review. The exam¬ples of detecting autoantibodies against aminoacyl-tRNA synthetases, ribosomes and ribosomal proteins under certain autoimmune pathologies are considered. Their properties given in comparison with structural and functional peculiarities of autoantibodies against the other types of the cellular cytoplasmic RNP as well as the nuclear ones are partially characterized. The main hypothesis for the origin of autoantibodies and their functional significance in normal and immunopathological states are presented.