Biopolymers and cell. 1991. Volume 7. № 3. 49 - 54

IVASCHENKO T. E., LIVSHITZ L. A., GEMBOVSKAYA S. A. AMOASHIY D S. VENOZINSKIS M. T., GORBUNOVA V. N., BARANOV V. S.

Comparative Analysis of Deletion F508 Frequency in Fibrosis Patients

Summary

    The ferquency of F508 deletion has been studies by polymerase chain reaction in 114 CF patients of North-West part of the USSR, in 31 CF patients from Ukraina, 14 from Moldovia and 8 from Lithuania. 77 % of CF choromosomes from Ukrainian CF patients with severe mixed pancreatic-pulmonar forms of disease and 65 % CF chromosomes of similar CF patients from North-Western part of the USSR carried AF508 while its frequency in Moldavian and Lithuania CF patients was significantly less (26 and 25 % respectively). 96% Slavonian patients of North-Western part and 92% Slavonian CF patients from Ukraina were either heterozygos or homozygos for the deletion F508. 90 % of F508 chromosomes possessed haplotype 2, 2, 2, 1 for polymorphic sites KM19, CS7, MP6d9, XV2c, respectively. Obvions significance at these data for the most effective pre- and postnatal diagnosis of CF and carrier detection is discussed.