Biopolymers and cell. 1990. Volume 6. № 6. 89 - 92, 99

A. I. Medvedev, G. I. Revina

ACIDIC POLYPEPTIDES AS INHIBITORS OF THE REPAIR OF DOUBLE-STRAND DNA BREAKS

Summary

    The ability of polypeptides consisting of aspartic and glutamic acids to inhibit the repair of double-strand DNA breaks induced in Y-irradiated Chinese hamster and HeLa cells was shown. A complete inhibiton of the double-strand DNA breaks repair was observed under the concentrations of 20 jimoles/1 (polyglutamic acid with molecular weight 2000—15000 daltons) and 100 umoles/1 (aspartylglutamic acid with moSccuar weight 1500-4500 daltons). Both polypeptides were low toxic at the given concentrations, their inhibitory effect being reversible.