Biopolymers and cell. 1990. Volume 6. № 6. 59 - 63

I. A. Shakhmuradov, V. A. Gasutnov

METHOD OF COMPUTER SEARCH OF HOMOLOGOUS SITES WITH THE POSSIBLE INSERTIONS/DELETIONS IN THE NUCLEOTIDE SEQUENCES AND EVALUATION OF THEIR STATISTICAL SIGNIFICANCE

Summary

    A computer method which allows revealing all the homologous sites with the given cha¬racteristics (the site's length, number of distinctions, number and size of deletions / inser¬tions) in one nucleotide sequence or between two DNA (RNA) sequences and evaluating the statistical significance of the found homologies was developed. This method is espe¬cially effective for the search of potential stem-loop structures in the nucleotide sequences and can be used to align the two DNA (RNA) sequences.