Biopolymers and cell. 1990. Volume 6. № 5. 59 - 64

E. M. Ostolovsky, A. D. Botsyansky, S. N. Borisenko, N. V. Tolkachova

MOLECULAR ORGANIZATION OF HUMAN SERUM ALBUMIN STRUCTURE

Summary

    Physicochemical methods (IR- and NMR-spectroscopy, circular dichroism, etc.) that hu¬man serum albumin molecule is a compact globule with 50 % spiral structure and with exposition of a half of tyrozil on its surface. At the same time considerable percent of polypeptide chain with disordely packed form and with small contribution of f5-struc-ture part is observed in the molecule space structure. Theoretical calculations of a-spi-ral parts localization in serum albumin molecule indicate that approximately equal num¬ber of amino acids residues is found in every of three domains.