Biopolymers and cell. 1990. Volume 6. № 5. 5 - 23

E. B. Paton

PECULIARTIES OF EXPRESSION REGULATION OF THE rplKAJL GENE CLUSTER

Summary

    The review is focused on the evolutionary point of structure and functional organization of the rplKAJL gene cluster, characteristics of the LI and L10 regulatory ribosomal pro¬teins and structural features of the L10-L7/L12 mRNA leader sequence, which contains a L10 binding site. The principles and specific features of the translational control of rplKAJL genes expression are considered and the regulatory mechanism, providing for the excess synthesis of L7/L12 protein in vivo is proposed. Peculiarities of recombinant molecules, caused by elevation of the cloned rplKAJL gene dosage in the cell, are discus¬sed as well.