Biopolymers and cell. 1990. Volume 6. № 3. 55 - 59

A. A. Kiladze, V. G. Birkaya, E. M. Lomidze, I. R. Monaselidze

STUDIES IN pH-DBPENDENT STRUCTURAL AND FUNCTIONAL PROPERTIES OF LACTATE DEHYD'ROGENASE IN THE PRESENCE OF ZINC IONS

Summary

    The effect of zinc, cobalt and nickel ions on the LDH structure and function was studied. Calorimetric data have revealed essentially different melting character of LDH and LDH bound with zinc, cobalt, and nickel ions. It is noteworthy that one zinc ion binding is specific for LDH M4. It is shown that zinc ion binding causes the changes in the LDH kinetic properties, no changes in LDH secondary structure occurring.