Biopolymers and cell. 1990. Volume 6. № 2. 76 - 80
T. G. Titok, I. E. Kostetsky, T. L. Chaikovskaya, T. P. Kochubej, L. G. Zharova, S. D. Kirilenko, I. M. Melnik, E. M. Silvanskaya, T. I. Buzhievskaya, V. A. Kordium
TRANSFER OF HUMAN PREPROINSULIN GENE INTO STREPTOZOTOCIN DIABETIC RATS
Summary
Recombinans plasmid encapsulated in liposomes containing DNA sequences of human preproinsulin gene (pAINS) was injected into the liver of streptozotocin diabetic rats. The ijection of pAINS decreased glycemia level and increased immunoreactive blood product concentration. Maximal effect was detected 6—8 h after injection, and insulin concentration returned to their initial levels after injection.