Biopolymers and cell. 1989. Volume 5. № 2. 36 - 43

S. M. Landau

POSSIBILITIES OF USING VECTORS ON THE BASIS OF DNA SV40 FOR GENE THERAPY

Summary

    It is shown possible to use eukaryotic vectors on the basis of vacuolating virus SV40 for introduction into animal organism and, even in perspective, into the human organism, The main advantages of SV40-based vectors are small sizes of regulatory sequences and ability to integrate into the mammalian cells, including the human cells, in the absence of T-antigen inducing malignant cell transformation.