Biopolymers and cell. 1989. Volume 5. № 1. 89 - 93

A. V. Finkelstein

IS IT POSSIBLE TO GRAFT AN «ALIEN» ACTIVE SITE ON A PROTEIN GLOBULE?

Summary

    If a protein globule serves only as a rigid «foundation» for the active site, then the other «alien» active site can be «grafted» onto it by site-directed mutagenesis. Under this hypothesis, the mutations are singled out which should be introduced to the T4 phage lysozyme to «graft» it the protease activity.