Biopolymers and cell. 1988. Volume 4. № 6. 329 - 333

A. L, Kalvelyte, L. J. Pabrezaite, M. R. Valius, K. V. Konstantinavicius

GROWTH PROMOTING ACTIVITY IN CULTURE OF SPONTANEOUS PROLIFERATING LEUKEMIC LYMPHOCYTES

Summary

    It is shown that leukemic lymphocytes from the peripheral blood of bovine with chronic lymphocytic leukemia proliferate in the serum-free Eagle medium in the absence of exogenous growth factors and mitogenic stimulation. The nondializable, thermostable, trypsin sensitive growth promoting activity is determined in the culture medium condi¬tioned by leukemic cells. The results suggest that circulating leukemic lymphocytes are capable of elaborating growth factors to which they can respond.